Unraveling the Complexity of Amyotrophic Lateral Sclerosis Survival Prediction.

ABSTRACT: Objective: The heterogeneity of amyotrophic lateral sclerosis (ALS) survival duration, which varies from <1 year to >10 years, challenges clinical decisions and trials. Utilizing data from 801 deceased ALS patients, we: (1) assess the underlying complex relationships among common clinical ALS metrics; (2) identify which clinical ALS metrics are the "best" survival predictors and how their predictive ability changes as a function of disease progression. Methods: Analyses included examination of relationships within the raw data as well as the construction of interactive survival regression and classification models (generalized linear model and random forests model). Dimensionality reduction and feature clustering enabled decomposition of clinical variable contributions. Thirt

SUBMITTER: Pfohl SR 

PROVIDER: S-EPMC6010549 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature