Inverse association of vitamin D₃ levels with lung cancer mediated by genetic variation.

ABSTRACT: Vitamin D is an essential micronutrient required for normal physiological function and recognized for its role regulating calcium metabolism. Recent work is beginning to emerge demonstrating a role for vitamin D in chronic illnesses, such as cancer. Circulating serum levels of 25(OH)D_2/3 were quantitatively measured using sensitive ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) in 406 lung cancer cases and 437 population controls, while 1,25(OH)₂ D_2/3 levels were measured in a subset of 90 cases and 104 controls using the same method, from the NCI-MD case-control cohort. 25(OH)D₃ levels were inversely associated with lung cancer status across quartiles (Q2 vs. Q1: OR_adjusted  = 0.5, 95% CI = 0.3

SUBMITTER: Haznadar M 

PROVIDER: S-EPMC6010700 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature