A common regulatory variant in SLC35B4 influences the recurrence and survival of prostate cancer.

ABSTRACT: Single nucleotide polymorphisms (SNPs) within the regulatory elements of a gene can alter gene expression, making these SNPs of prime importance for candidate gene association studies. We aimed to determine whether such regulatory variants are associated with clinical outcomes in three cohorts of patients with prostate cancer. We used RegulomeDB to identify potential regulatory variants based on in silico predictions and reviewed genome-wide experimental findings. Overall, 131 putative regulatory SNPs with the highest confidence score on predicted functionality were investigated in two independent localized prostate cancer cohorts totalling 458 patients who underwent radical prostatectomy. The statistically significant SNPs identified in these two cohorts were then tested in an additional

SUBMITTER: Huang EY 

PROVIDER: S-EPMC6010704 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature