In Situ One-Pot Synthesis of MOF-Polydopamine Hybrid Nanogels with Enhanced Photothermal Effect for Targeted Cancer Therapy.

ABSTRACT: Herein, a simple one-pot way is designed to prepare a type of multifunctional metal-organic framework (MOF)-based hybrid nanogels by in situ hybridization of dopamine monomer in the skeleton of MnCo. The resultant hybrid nanoparticles (named as MCP) show enhanced photothermal conversion efficiency in comparison with pure polydopamine or MnCo nanoparticles (NPs) synthesized under a similar method and, therefore, show great potential for photothermal therapy (PTT) in vivo. The MCP NPs are expected to possess T₁ positive magnetic resonance imaging ability due to the high-spin Mn-N6 (S = 5/2) in the skeleton of MnCo. To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arg

SUBMITTER: Wang D 

PROVIDER: S-EPMC6010715 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature