Establishment of a nine-gene prognostic model for predicting overall survival of patients with endometrial carcinoma.

ABSTRACT: Endometrial carcinoma (EC) is the most common malignant tumor of the female genital tract in developed countries. The prognosis of early stage EC is favorable, but a subset faces high risk of cancer progression or recurrence. EC has a poor prognosis upon progression to advanced or metastatic stages. Therefore, our goal is to build a robust prognostic model for predicting overall survival (OS) in EC patients. In this study, 1571 genes were identified as being associated with OS based on genomewide expression profiles using a training dataset. Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that these genes were involved in various cancer-related signaling pathways. Nine signature genes were further selected using stepwise selection, and their potential role in the devel

SUBMITTER: Ying J 

PROVIDER: S-EPMC6010780 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature