Angiotensin Type 2 Receptor Gene Polymorphisms and Susceptibility to Preeclampsia.

ABSTRACT:

Background

The purpose of the study was to determine the relationship between angiotensin II type 1 receptor at position+1166 (AT1R+1166A/C; rs5186) and angiotensin II type 2 receptor at position+1675 (AT2R+1675A/G; rs5194) gene polymorphisms with preeclampsia in an Iranian women population.

Methods

430 women were recruited in this study including 212 preeclamptics and 218 healthy women. PCR-RFLP method was used for genotyping the polymorphisms. Chi square and Fisher exact test were used for comparing case and control groups. The p<0.05 was considered statistically significant.

Results

The frequency of genotypes of the AT1R gene and AT2R gene was similar in preeclampsia and normal pregnancy. There were no significant differences in genotype and also allele frequencies

SUBMITTER: Soltani-Zangbar MS 

PROVIDER: S-EPMC6010826 | biostudies-literature | 2018 Apr-Jun

REPOSITORIES: biostudies-literature