Wolbachia enhances insect-specific flavivirus infection in Aedes aegypti mosquitoes.

ABSTRACT: Mosquitoes transmit a diverse group of human flaviviruses including West Nile, dengue, yellow fever, and Zika viruses. Mosquitoes are also naturally infected with insect-specific flaviviruses (ISFs), a subgroup of the family not capable of infecting vertebrates. Although ISFs are not medically important, they are capable of altering the mosquito's susceptibility to flaviviruses and may alter host fitness. Wolbachia is an endosymbiotic bacterium of insects that when present in mosquitoes limits the replication of co-infecting pathogens, including flaviviruses. Artificially created Wolbachia-infected Aedes aegypti mosquitoes are being released into the wild in a series of trials around the globe with the hope of interrupting dengue and Zika virus transmission from mosqui

SUBMITTER: Amuzu HE 

PROVIDER: S-EPMC6010864 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature