Combining Pathway Identification and Breast Cancer Survival Prediction via Screening-Network Methods.

ABSTRACT: Breast cancer is one of the most common invasive tumors causing high mortality among women. It is characterized by high heterogeneity regarding its biological and clinical characteristics. Several high-throughput assays have been used to collect genome-wide information for many patients in large collaborative studies. This knowledge has improved our understanding of its biology and led to new methods of diagnosing and treating the disease. In particular, system biology has become a valid approach to obtain better insights into breast cancer biological mechanisms. A crucial component of current research lies in identifying novel biomarkers that can be predictive for breast cancer patient prognosis on the basis of the molecular signature of the tumor sample. However, the high dimension and l

SUBMITTER: Iuliano A 

PROVIDER: S-EPMC6011013 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature