Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients.

ABSTRACT:

Background

Transforming growth factor-β (TGF-β) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF-β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients.

Methods

We studied 120 CKD patients and 40 healthy controls. Serum TGF-β1, TGF-β2, TGF-β3, endotoxin, and inflammatory markers were measured. Functional polymorphisms in the TGF-β1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography.

Results

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SUBMITTER: Hassan MO 

PROVIDER: S-EPMC6011064 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature