Cysteine boosters the evolutionary adaptation to CoCl₂ mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the second most common gynaecologic malignancy and the most common cause of death from gynaecologic cancer, especially due to diagnosis at an advanced stage, when a cure is rare. As ovarian tumour grows, cancer cells are exposed to regions of hypoxia. Hypoxia is known to be partially responsible for tumour progression, metastasis and resistance to therapies. These suggest that hypoxia entails a selective pressure in which the adapted cells not only have a fitness increase under the selective environment, but also in non-selective adverse environments. In here, we used two different ovarian cancer cell lines - serous carcinoma (OVCAR3) and clear cell carcinoma (ES2) - in order to address the effect of cancer cells selection under normoxia and hypoxia mim

SUBMITTER: Nunes SC 

PROVIDER: S-EPMC6011206 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature