RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

ABSTRACT: Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq analysis upon microglia isolated from the hippocampus to determine expression pattern alterations following kainic acid induced seizure. We determined that microglia undergo dramatic changes to their expression patterns, particularly with regard to mitochondrial activity and metabolism. We also observed that microglia initiate immunological activity, specifically increasing interferon beta responsiveness. Our results provide novel insights into microglia transcriptional regulation following acute seizures and suggest potential therapeutic target

SUBMITTER: Bosco DB 

PROVIDER: S-EPMC6011524 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature