Novel insights into the mechanism of SepL-mediated control of effector secretion in enteropathogenic Escherichia coli.

ABSTRACT: Type three secretion systems (T3SSs) are virulence determinants employed by several pathogenic bacteria as molecular syringes to inject effector proteins into host cells. Diarrhea-producing enteropathogenic Escherichia coli (EPEC) uses a T3SS to colonize the intestinal tract. T3S is a highly coordinated process that ensures hierarchical delivery of three classes of substrates: early (inner rod and needle subunits), middle (translocators), and late (effectors). Translocation of effectors is triggered upon host-cell contact in response to different environmental cues, such as calcium levels. The T3S substrate specificity switch from middle to late substrates in EPEC is regulated by the SepL and SepD proteins, which interact with each other and form a trimeric complex with the chaperone CesL.

SUBMITTER: Gaytan MO 

PROVIDER: S-EPMC6011996 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature