GERM-06. REDUCED RADIOTHERAPY DOSE AND VOLUME FOLLOWING CHEMOTHERAPY FOR INTRACRANIAL GERMINOMA WITH B-HCG LEVEL < 200 MIU/ML: PRELIMINARY RESULTS OF SMC G-13 TRIAL

ABSTRACT: Abstract

PURPOSE

We performed a prospective single arm trial (NCT02782754) to investigate whether pre-RT chemotherapy could reduce the necessary dose and volume of RT while preventing relapse/progression of intracranial germinoma with b-HCG level < 200 mIU/mL.

METHODS

A total of 32 patients who were diagnosed with intracranial germinoma with b-HCG level < 200 mIU/mL were enrolled in this study. Four cycles of chemotherapy were given prior to RT. A 18 Gy of craniospinal RT for M+ tumors, whole brain RT for basal ganglia tumor, otherwise whole ventricle RT followed by 12.6 Gy of local RT to the primary site was administered following pre-RT chemotherapy.

RESULT

The site of primary tumor was suprasellar in 10, pineal in 10, bifocal in 11, and basal ganglia in 1. Ten

SUBMITTER: Lee J 

PROVIDER: S-EPMC6012071 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature