Neutrophils are essential for induction of vaccine-like effects by antiviral monoclonal antibody immunotherapies.

ABSTRACT: Using a mouse retroviral model, we have shown that mAb-based immunotherapy can induce life-long endogenous protective immunity (vaccine-like effects). This observation has potentially important consequences for treating life-threatening human viral infections. Here, we investigated the role of neutrophils in this effect. Neutrophils are innate immunity effector cells with well-established microbe-killing activities that are rapidly mobilized upon infection. They are also emerging as orchestrators of innate and adaptive immunities. However, their immunomodulatory activity during antiviral mAb immunotherapies has never been studied. Our data reveal that neutrophils have an essential role in immunotherapy-induced immune protection of infected mice. Unexpectedly, neutrophils have a limited eff

SUBMITTER: Naranjo-Gomez M 

PROVIDER: S-EPMC6012508 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature