Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment.

ABSTRACT: Sepsis-associated encephalopathy manifesting as delirium is a common problem in critical care medicine. In this study, patients that had delirium due to sepsis had significant cognitive impairments at 12-18 months after hospital discharge when compared with controls and Cambridge Neuropsychological Automated Test Battery-standardized scores in spatial recognition memory, pattern recognition memory, and delayed-matching-to-sample tests but not other cognitive functions. A mouse model of S. pneumoniae pneumonia-induced sepsis, which modeled numerous aspects of the human sepsis-associated multiorgan dysfunction, including encephalopathy, also revealed similar deficits in spatial memory but not new task learning. Both humans and mice had large increases in chemokines for myeloid cell recruitme

SUBMITTER: Andonegui G 

PROVIDER: S-EPMC6012517 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature