Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques.

ABSTRACT:

Aims

Identification and treatment of the rupture prone atherosclerotic plaque remains a challenge for reducing the burden of cardiovascular disease. The interconnection of metabolic and inflammatory processes in rupture prone plaques is poorly understood. Herein, we investigate associations between metabolite profiles, inflammatory mediators and vulnerability in carotid atherosclerotic plaques.

Methods and results

We collected 159 carotid plaques from patients undergoing endarterectomy and measured 165 different metabolites in a targeted metabolomics approach. We identified a metabolite profile in carotid plaques that associated with histologically evaluated vulnerability and inflammatory mediators, as well as presence of symptoms in patients. The distinct metabolite profile

SUBMITTER: Tomas L 

PROVIDER: S-EPMC6012762 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature