Genetic profile and patient-reported outcomes in chronic obstructive pulmonary disease: A systematic review.

ABSTRACT:

Background

Chronic Obstructive Pulmonary Disease (COPD) impacts differently on patients at similar grades, suggesting that factors other than lung function may influence patients' experience of the disease. Recent studies have found associations between genetic variations and patient-reported outcomes (PROs). Identifying these associations might be fundamental to predict the disease progression and develop tailored interventions. This systematic review aimed to identify the genetic variations associated with PROs in COPD.

Methods and findings

Databases were searched until July 2017 (PROSPERO: CRD42016041639) and additional searches were conducted scanning the reference list of the articles. Two independent reviewers assessed the quality of studies using the Q-Genie checklist

SUBMITTER: Melro H 

PROVIDER: S-EPMC6013101 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature