Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes.

ABSTRACT:

Background

A new type of influenza virus, known as type D, has recently been identified in cattle and pigs. Influenza D virus infection in cattle is typically asymptomatic; however, its infection in swine can result in clinical disease. Swine can also be infected with all other types of influenza viruses, namely A, B, and C. Consequently, swine can serve as a "mixing vessel" for highly pathogenic influenza viruses, including those with zoonotic potential. Currently, the only antiviral drug available targets influenza M2 protein ion channel is not completely effective. Thus, it is necessary to develop an M2 ion channel blocker capable of suppressing the induction of resistance to the genetic shift. To provide a basis for developing novel ion channel-blocking compounds, we investigat

SUBMITTER: Kesinger E 

PROVIDER: S-EPMC6013169 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature