Total Synthesis Confirms the Molecular Structure Proposed for Oxidized Levuglandin D₂.

ABSTRACT: Levuglandins (LG)D₂ and LGE₂ are γ-ketoaldehyde levulinaldehyde derivatives with prostanoid side chains produced by spontaneous rearrangement of the endoperoxide intermediate PGH₂ in the biosynthesis of prostaglandins. Covalent adduction of LGs with the amyloid peptide Aβ_1-42 promotes formation of the type of oligomers that have been associated with neurotoxicity and are a pathologic hallmark of Alzheimer's disease. Within 1 min of their generation during the production of PGH₂ by cyclooxygenation of arachidonic acid, LGs are sequestered by covalent adduction to proteins. In view of this high proclivity for covalent adduction, it is understandable that free LGs have never been detected in vivo. Recently a catabolite, believed to be an

SUBMITTER: Cheng YS 

PROVIDER: S-EPMC6013286 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature