Effect of connective tissue growth factor delivered via porous sutures on the proliferative stage of intrasynovial tendon repair.

ABSTRACT: Recent growth factor, cell, and scaffold-based experimental interventions for intrasynovial flexor tendon repair have demonstrated therapeutic potential in rodent models. However, these approaches have not achieved consistent functional improvements in large animal trials due to deleterious inflammatory reactions to delivery materials and insufficient induction of targeted biological healing responses. In this study, we achieved porous suture-based sustained delivery of connective tissue growth factor (CTGF) into flexor tendons in a clinically relevant canine model. Repairs with CTGF-laden sutures were mechanically competent and did not show any evidence of adhesions or other negative inflammatory reactions based on histology, gene expression, or proteomics analyses at 14 days following re

SUBMITTER: Linderman SW 

PROVIDER: S-EPMC6013340 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature