Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.

ABSTRACT: Comparative analysis of human and animal model melanomas can uncover conserved pathways and genetic changes that are relevant for the biology of cancer cells. Spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny may be informative in identifying genes and functional pathways that are similarly related to melanoma development in all vertebrates, including humans. To assess functional pathways involved in the Xiphophorus melanoma, we performed gene expression profiling of the melanomas produced in interspecies BC₁ and successive backcross generations (i.e., BC₅ ) of the cross: X. hellerii × [X. maculatus Jp 163 A × X. hellerii]. Using RNA-Seq, we identified genes that are transcriptionally co-expressed with the driver oncogene, xmrk. We determined f

SUBMITTER: Lu Y 

PROVIDER: S-EPMC6013346 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature