Reuse of public, genome-wide, murine eosinophil expression data for hypotheses development.

ABSTRACT: The eosinophil (Eos) surface phenotype and activation state is altered after recruitment into tissues and after exposure to pro-inflammatory cytokines. In addition, distinct Eos functional subsets have been described, suggesting that tissue-specific responses for Eos contribute to organ homeostasis. Understanding the mechanisms by which Eos subsets achieve their tissue-specific identity is currently an unmet goal for the eosinophil research community. Publicly archived expression data can be used to answer original questions, test and generate new hypotheses, and serve as a launching point for experimental design. With these goals in mind, we investigated the effect of genetic background, culture methods, and tissue residency on murine Eos gene expression using publicly available, genome-w

SUBMITTER: Grace JO 

PROVIDER: S-EPMC6013373 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature