Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study.

ABSTRACT:

Background

Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined.

Hypothesis

Low serum androgens are associated with an increased risk of AF.

Methods

We examined the prospective associations between testosterone, its more active metabolite dihydrotestosterone (DHT), and sex hormone-binding globulin (SHBG) with risk of AF among 1019 otherwise healthy men with average age 76.3 ±4.9 years in the Cardiovascular Health Study.

Results

After median follow-up of 9.5 years, 304 (30%) men developed AF. We detected a nonlinear association with risk of incident AF in both free and total DHT, in which subjects with the lowest levels had a highe

SUBMITTER: Rosenberg MA 

PROVIDER: S-EPMC6013387 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature