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Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade.

ABSTRACT: BACKGROUND:Patients with high-risk prostate cancer have an increased likelihood of experiencing a relapse following radical prostatectomy (RP). We previously conducted three neoadjuvant androgen-deprivation therapy (ADT) trials prior to RP in unfavorable intermediate and high-risk disease. METHODS:In this analysis, we report on the post-RP outcomes of a subset of patients enrolled on these studies. We conducted a pooled analysis of patients with available follow-up data treated on three neoadjuvant trials at three institutions. All patients received intense ADT prior to RP. The primary endpoint was time to biochemical recurrence (BCR). BCR was defined as a PSA???0.2?ng/mL or treatment with radiation or androgen-deprivation therapy for a rising PSA?

SUBMITTER: McKay RR 

PROVIDER: S-EPMC6013399 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Post prostatectomy outcomes of patients with high-risk prostate cancer treated with neoadjuvant androgen blockade.

McKay Rana R RR   Montgomery Bruce B   Xie Wanling W   Zhang Zhenwei Z   Bubley Glenn J GJ   Lin David W DW   Preston Mark A MA   Trinh Quoc-Dien QD   Chang Peter P   Wagner Andrew A AA   Mostaghel Elahe A EA   Kantoff Philip W PW   Nelson Peter S PS   Kibel Adam S AS   Taplin Mary-Ellen ME  

Prostate cancer and prostatic diseases 20171220 3

<h4>Background</h4>Patients with high-risk prostate cancer have an increased likelihood of experiencing a relapse following radical prostatectomy (RP). We previously conducted three neoadjuvant androgen-deprivation therapy (ADT) trials prior to RP in unfavorable intermediate and high-risk disease.<h4>Methods</h4>In this analysis, we report on the post-RP outcomes of a subset of patients enrolled on these studies. We conducted a pooled analysis of patients with available follow-up data treated on  ...[more]