Adipocytes induce distinct gene expression profiles in mammary tumor cells and enhance inflammatory signaling in invasive breast cancer cells.

ABSTRACT: Obesity is a known risk factor for breast cancer. Since obesity rates are constantly rising worldwide, understanding the molecular details of the interaction between adipose tissue and breast tumors becomes an urgent task. To investigate potential molecular changes in breast cancer cells induced by co-existing adipocytes, we used a co-culture system of different breast cancer cell lines (MCF-7 and T47D: ER⁺/PR⁺/HER2^- and MDA-MB-231: ER^-/PR^-/HER2^-) and murine 3T3-L1 adipocytes. Here, we report that co-culture with adipocytes revealed distinct changes in global gene expression pattern in the different breast cancer cell lines. Our microarray data revealed that in both ER⁺ cell lines, top upregulated genes showed sig

SUBMITTER: Nickel A 

PROVIDER: S-EPMC6013441 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature