Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans.

ABSTRACT: Differences in tumor characteristics might partially account for mortality disparities between African American (AA) and European American (EA) colorectal cancer patients. We evaluated effect modification by race for exposure and patient-outcomes associations with colorectal tumor methylation among 218 AA and 267 EA colorectal cancer cases from the population-based North Carolina Colon Cancer Study. Tumor methylation was assessed in CACNA1G, MLH1, NEUROG1, RUNX3, and SOCS1. We used logistic regression to assess whether associations between several lifestyle factors-intake of fruits, vegetables, folate, and non-steroidal anti-inflammatory drugs-and tumor methylation were modified by race. Proportional hazards models were used to evaluate whether race modified associations between tumor meth

SUBMITTER: Busch EL 

PROVIDER: S-EPMC6013500 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature