The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients.

ABSTRACT: PURPOSE:Current guidelines recommend maintaining a mean arterial pressure (MAP) ≥ 65 mmHg in septic patients. However, the relationship between hypotension and major complications in septic patients remains unclear. We, therefore, evaluated associations of MAPs below various thresholds and in-hospital mortality, acute kidney injury (AKI), and myocardial injury. METHODS:We conducted a retrospective analysis using electronic health records from 110 US hospitals. We evaluated septic adults with intensive care unit (ICU) stays ≥ 24 h from 2010 to 2016. Patients were excluded with inadequate blood pressure recordings, poorly documented potential confounding factors, or renal or myocardial histories documented within 6 months of ICU admission. Hypotension exposure was defined by time-weighted av

SUBMITTER: Maheshwari K 

PROVIDER: S-EPMC6013508 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature