Plasma glutamine and glutamic acid are potential biomarkers for predicting diabetic retinopathy.

ABSTRACT:

Introduction

Diabetic patients with a long disease duration usually accompanied complication such as diabetic retinopathy, but in some patients had no complication.

Objectives

We analyzed differences in plasma metabolites according to the presence or absence of diabetic retinopathy (DR) in type 2 diabetic (T2D) patients with disease duration ≥ 15 years.

Methods

A cohort of 183 T2D patients was established. Their biospecimens and clinical information were collected in accordance with the guidelines of the National Biobank of Korea, and the Korean Diabetes Association. DR phenotypes of the subjects were verified by ophthalmologic specialists. Plasma metabolites were analyzed using gas chromatography time-of-flight mass spectrometry and ultra-performance liquid chromatog

SUBMITTER: Rhee SY 

PROVIDER: S-EPMC6013531 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature