Functional Plasticity of Gamma Delta T Cells and Breast Tumor Targets in Hypoxia.

ABSTRACT: Interactions between immune and tumor cells in the tumor microenvironment (TME) often impact patient outcome, yet remain poorly understood. In addition, the effects of biophysical features such as hypoxia [low oxygen (O₂)] on cells within the TME may lead to tumor evasion. Gamma delta T cells (γδTcs) naturally kill transformed cells and are therefore under development as immunotherapy for various cancers. Clinical trials have proven the safety of γδTc immunotherapy and increased circulating γδTc levels correlate with improved patient outcome. Yet, the function of γδTc tumor infiltrating lymphocytes in human breast cancer remains controversial. Breast tumors can be highly hypoxic, thus therapy must be effective under low O₂ conditions. We have found increased infiltrat

SUBMITTER: Siegers GM 

PROVIDER: S-EPMC6013583 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature