In Search for Reliable Markers of Glioma-Induced Polarization of Microglia.

ABSTRACT: Immune cells accumulating in the microenvironment of malignant tumors are tumor educated and contribute to its growth, progression, and evasion of antitumor immune responses. Glioblastoma (GBM), the common and most malignant primary brain tumor in adults, shows considerable accumulation of resident microglia and peripheral macrophages, and their polarization into tumor-supporting cells. There are controversies regarding a functional phenotype of glioma-associated microglia/macrophages (GAMs) due to a lack of consistent markers. Previous categorization of GAM polarization toward the M2 phenotype has been found inaccurate because of oversimplification of highly complex and heterogeneous responses. In this study, we characterized functional responses and gene expression in mouse and human mic

SUBMITTER: Walentynowicz KA 

PROVIDER: S-EPMC6013650 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature