Gut Microbiome Analysis Identifies Potential Etiological Factors in Acute Gastroenteritis.

ABSTRACT: The morbidity and mortality resulting from acute gastroenteritis and associated chronic sequelae represent a substantial burden on health care systems worldwide. Few studies have investigated changes in the gut microbiome following an episode of acute gastroenteritis. By using nondirected 16S rRNA gene amplicon sequencing, the fecal microbiota of 475 patients with acute gastroenteritis was examined. Patient age was correlated with the overall microbial composition, with a decrease in the abundance of Faecalibacterium being observed in older patients. We observed the emergence of a potential Escherichia-Shigella-dominated enterotype in a subset of patients, and this enterotype was predicted to be more proinflammatory than the other common enterotypes, with the latter being dom

SUBMITTER: Castano-Rodriguez N 

PROVIDER: S-EPMC6013661 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature