OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds.

ABSTRACT: Nowadays, the number of chronic trauma cases caused by a variety of factors such as the world's population-ageing and chronic diseases is increasing steadily, and thus effective treatment for chronic wounds has become a severe clinical challenge, which also burdens the patient both physically and financially. Therefore, it is urgent to develop new drugs to accelerate the healing of wounds. Bioactive peptides, which are relatively low cost, easy to produce, store and transport, have become an excellent choice. In this research, we identified a novel peptide OA-GL21, with an amino acid sequence of 'GLLSGHYGRVVSTQSGHYGRG', from the skin secretions of Odorrana andersonii Our results showed that OA-GL21 exerted the ability to promote wound healing of human keratinocytes (HaCaT) and human fibrob

SUBMITTER: Bian W 

PROVIDER: S-EPMC6013704 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature