Correlates of Protection Against SIV_mac251 Infection in Rhesus Macaques Immunized With Chimpanzee-Derived Adenovirus Vectors.

ABSTRACT: We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)_mac239 tested in HAdV-seropositive rhesus macaques (RMs) repeatedly challenged rectally with low doses of SIV_mac251. Both vaccine regimens reduced set point and peak viral loads (PVL) and accelerated viral clearance. In SAdV-vaccinated controller genotype RMs resistance against infection correlated with levels of envelope (Env)-specific antibody (Ab) titers. In both vaccine groups CD8⁺T cells controlled viral loads (VL) upon infection. Circulating CD4⁺ and CD8⁺ T cells showed significant changes in their transcriptome over time following vaccinati

SUBMITTER: Tuyishime S 

PROVIDER: S-EPMC6013748 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature