A nuclear targeted dual-photosensitizer for drug-resistant cancer therapy with NIR activated multiple ROS.

ABSTRACT: Photodynamic therapy against cancer, especially multidrug resistant cancer, is limited seriously due to the efflux of photosensitizer molecules by P-glycoprotein, which leads to insufficient production of reactive oxygen species (ROS). For the purpose of abundant ROS generation and effective therapeutic response, herein, we firstly design and fabricate a nuclear targeted dual-photosensitizer for photodynamic therapy against multidrug resistant cancer. Molecule-photosensitizer Ce6 was selected and modified on the surface of core/shell structure nano-photosensitizer upconversion@TiO₂ and then nuclear targeted peptides TAT were anchored for nuclear targeting. Through selective doping of rare earth elements Er and Tm, multiple ROS (˙OH, O₂˙^-, and ¹O<

SUBMITTER: Yu Z 

PROVIDER: S-EPMC6013803 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature