Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study.

ABSTRACT:

Objective

Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected.

Design

Pregnancy cohort study.

Setting

Pittsburgh, PA, USA.

Population

Women with PTB (n = 115) and term births (n = 210) evaluated 4-12 years after pregnancy.

Methods

Cardiometabolic risk markers were compared in women with prior PTB versus term births; pre-eclampsia and growth restriction cases were excluded. Placental evidence of maternal vascular malperfusion (vasculopathy, infarct, advanced villous maturation, perivillous fibrin, intervillous fibrin deposition), acute infection/inflammation (chorioamnionitis, funisitis, deciduitus) and villitis

SUBMITTER: Catov JM 

PROVIDER: S-EPMC6013820 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature