An enzyme-activatable and cell-permeable Mn^III-porphyrin as a highly efficient T₁ MRI contrast agent for cell labeling.

ABSTRACT: Magnetic resonance imaging (MRI) is a preferred technique for noninvasively monitoring the fate of implanted cells, such as stem cells and immune cells in vivo. Cellular MRI requires contrast agents (CAs) to label the cells of interest. Despite promising progress made in this emerging field, highly sensitive, stable and biocompatible T₁ CAs with high cell permeability and specificity remains an unmet challenge. To address this need, a novel Mn^III-porphyrin, MnAMP was designed and synthesized based on the modification of Mn^IIItetra(carboxy-porphyrin) (MnTCP), a small and highly stable non-Gd extracellular CA with good biocompatibility and high T₁ relaxivity (r₁ = 7.9 mM^-1 s^-1) at clinica

SUBMITTER: Haedicke IE 

PROVIDER: S-EPMC6013825 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature