Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease.

ABSTRACT:

Background

Bicuspid aortic valve (BAV) disease is the most common congenital cardiac abnormality affecting 1-2% of the population and is associated with a significantly increased risk of ascending aortic aneurysm. However, predicting which patients will develop aneurysms remains a challenge. This pilot study aimed to identify candidate plasma biomarkers for monitoring ascending aortic diameter and predicting risk of future aneurysm in BAV patients.

Methods

Plasma samples were collected pre-operatively from BAV patients undergoing aortic valve surgery. Maximum ascending aortic diameter was measured on pre-operative transoesophageal echocardiography. Maximum diameter ≥ 45 mm was classified as aneurysmal. Sequential Window Acquisition of all THeoretical Mass Spectra (SWATH-MS),

SUBMITTER: Harrison OJ 

PROVIDER: S-EPMC6013884 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature