Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases.

ABSTRACT: Background: Prostate smooth muscle contraction plays an important role for pathophysiology and treatment of male lower urinary tract symptoms (LUTS) but is incompletely understood. Because the efficacy of available medication is limited, novel options and improved understanding of prostate smooth muscle contraction are of high demand. Recently, a possible role of polo-like kinase 1 (PLK1) has been suggested for smooth muscle contraction outside the lower urinary tract. Here, we examined effects of PLK inhibitors on contraction of human prostate tissue. Methods: Prostate tissues were obtained from radical prostatectomy. RT-PCR, Western blot and immunofluorescence were performed to detect PLK expression and phosphorylated PLK. Smooth muscle contractions were induced by electric

SUBMITTER: Hennenberg M 

PROVIDER: S-EPMC6013909 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature