Real time monitoring of aminothiol level in blood using a near-infrared dye assisted deep tissue fluorescence and photoacoustic bimodal imaging.

ABSTRACT: The development of molecular probes for the detection and imaging of biological thiols is a major step forward diagnosing various types of diseases. Previously reported thiol imaging strategies were mainly based on a single mode of imaging with a limited application in vivo. In this work, we introduced an unsymmetrical near-infrared (NIR) squaraine dye (USq) as an exogenous contrast agent for photoacoustic and fluorescence bimodal imaging of thiol variations in live animals. USq exhibits a narrow absorption band at 680 nm that generates a photoacoustic signal and a strong NIR emission at 700 nm (Φ_F = 0.27), which is applicable for deep tissue optical imaging. Both photoacoustic and fluorescence signals could selectively disappear in the presence of different thiols

SUBMITTER: Anees P 

PROVIDER: S-EPMC6013924 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature