Cation-mediated optical resolution and anticancer activity of chiral polyoxometalates built from entirely achiral building blocks.

ABSTRACT: We report the crystallization of homochiral polyoxometalate (POM) macroanions {CoSb₆O₄(H₂O)₃[Co(hmta)SbW₈O₃₁]₃}^15- (1, hmta = hexamethylenetetramine) via the counter cation-mediated chiral symmetry breaking and asymmetric autocatalytic processes. In the presence of low Co²⁺ concentrations both Δ- and Λ-enantiomers of 1 formed in the reaction, crystallizing into the racemic crystal rac-1. At a high Co²⁺ concentration, the polyoxoanion enantiomers showed a high level of chiral recognition via H-bonding interactions to crystallize into enantiopure crystals of Δ- or Λ-[Co(H₂O)₆{CoSb₆O₄(H₂O)

SUBMITTER: Zhang ZM 

PROVIDER: S-EPMC6013930 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature