The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer.

ABSTRACT:

Background

Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. However, the role of semaphorin 5A in cervical cancer is not known. Our aim is to investigate the prognostic value of semaphorin 5A and its potential role in lymphangiogenesis and invasion in cervical cancer.

Methods

In this study, pathological features and clinical data of 232 cervical cancer patients were retrospectively reviewed. Semaphorin 5A protein and mRNA expression was detected by immunohistochemistry and quantitative real-time reverse transcription-polymerase chain reaction, respectively. In vitro, we determined the role and mechanistic pathways of semaphorin 5A in tumor progression in cervical carcinoma cell lines.

Results

Semaphorin 5A expression was si

SUBMITTER: Xiao JB 

PROVIDER: S-EPMC6013961 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature