Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Dengue and West Nile viruses are highly cross-reactive and have numerous parallels in geography, potential vector host (Aedes family of mosquitoes), and initial symptoms of infection. While the vast majority (> 80%) of both dengue and West Nile virus infections result in asymptomatic infections, a minority of individuals experience symptomatic infection and an even smaller proportion develop severe disease. The mechanisms by which these infections lead to severe disease in a subset of infected individuals is incompletely understood, but individual host differences including genetic factors and immune responses have been proposed. We sought to identify genetic risk factors that are associated with more severe disease outcomes for both viruses in order to shed light on pos

SUBMITTER: Cahill ME 

PROVIDER: S-EPMC6014009 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature