Genetic restriction of antigen-presentation dictates allergic sensitization and disease in humanized mice.

ABSTRACT:

Background

Immunoglobulin(Ig)E-associated allergies result from misguided immune responses against innocuous antigens. CD4⁺ T lymphocytes are critical for initiating and perpetuating that process, yet the crucial factors determining whether an individual becomes sensitized towards a given allergen remain largely unknown.

Objective

To determine the key factors for sensitization and allergy towards a given allergen.

Methods

We here created a novel human T cell receptor(TCR) and human leucocyte antigen (HLA)-DR1 (TCR-DR1) transgenic mouse model of asthma, based on the human-relevant major mugwort (Artemisia vulgaris) pollen allergen Art v 1 to examine the critical factors for sensitization and allergy upon natural allergen exposure via the airways in the absen

SUBMITTER: Neunkirchner A 

PROVIDER: S-EPMC6014064 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature