Effects of uric acid-lowering therapy on the progression of chronic kidney disease: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Whether uric acid levels were associated with the progression of chronic kidney disease (CKD) remained controversial. This meta-analysis was aimed to assess the effect of lowering serum uric acid therapy on the progression of CKD to clarify the role of uric acid in the progression of CKD indirectly.

Methods

Pubmed, Embase, the Cochrane library, CBM were searched for randomized controlled trials (RCTs) that assessed the efficiency of lowering serum uric acid therapy on the progression of CKD without language restriction. Summary estimates of weighted mean differences (WMDs) and relative risk (RR) were obtained by using random-effect or fixed-effect models. Sensitivity analyses were performed to identify the source of heterogeneity.

Results

A total of 12 rand

SUBMITTER: Liu X 

PROVIDER: S-EPMC6014338 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature