Hemoglobin A_1c Accurately Predicts Continuous Glucose Monitoring-Derived Average Glucose in Youth and Young Adults With Cystic Fibrosis.

ABSTRACT:

Objective

In cystic fibrosis (CF), hemoglobin A_1c (HbA_1c) is thought to underestimate glycemia. However, few studies have directly assessed the relationship between HbA_1c and average glucose in CF. We determined the relationships among glycemic markers-HbA_1c, fructosamine (FA), glycated albumin (%GA), and 1,5-anhydroglucitol (1,5-AG)-and continuous glucose monitoring (CGM) in CF, hypothesizing that alternate markers would better predict average sensor glucose (ASG) than HbA_1c.

Research design and methods

CF participants and a group of healthy control subjects (HCs), ages 6-25 years, wore CGM for up to 7 days. Pearson correlations assessed the relationships between CGM variables and HbA_1c, FA, %GA, and 1,5-AG.

SUBMITTER: Chan CL 

PROVIDER: S-EPMC6014540 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature