Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

ABSTRACT: The ordered assembly of amyloidogenic proteins causes a wide spectrum of common neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. These diseases share common features with prion diseases, in which misfolded proteins can self-replicate and transmit disease across different hosts. Deciphering the molecular mechanisms that underlie the amplification of aggregates is fundamental for understanding how pathological deposits can spread through the brain and drive disease. Here, we used single-molecule microscopy to study the assembly and replication of tau at the single aggregate level. We found that tau aggregates have an intrinsic ability to amplify by filament fragmentation, and determined the doubling times for this replication process by kinetic modeling. We then si

SUBMITTER: Kundel F 

PROVIDER: S-EPMC6014609 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature