Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture.

ABSTRACT: Neuronal-glial relationships play a critical role in the maintenance of central nervous system architecture and neuronal specification. A deeper understanding of these relationships can elucidate cellular cross-talk capable of sustaining proper development of neural tissues. In the cerebellum, cerebellar granule neuron precursors (CGNPs) proliferate in response to Purkinje neuron-derived Sonic hedgehog (Shh) before ultimately exiting the cell cycle and migrating radially along Bergmann glial fibers. However, the function of Bergmann glia in CGNP proliferation remains not well defined. Interestingly, the Hh pathway is also activated in Bergmann glia, but the role of Shh signaling in these cells is unknown. In this study, we show that specific ablation of Shh signaling using the tamoxifen-in

SUBMITTER: Cheng FY 

PROVIDER: S-EPMC6014626 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature