Testosterone treatment and the risk of aggressive prostate cancer in men with low testosterone levels.

ABSTRACT:

Purpose

Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP.

Materials and methods

Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific antigen (PSA) testing; excluding those with recent testosterone treatment, prostate or breast cancer, high PSA or prior prostate biopsy. Histologically-confirmed incident aggressive prostate cancer or any prostate cancer were the primary and secondary outcomes, respectively.

Results

Of the 1

SUBMITTER: Walsh TJ 

PROVIDER: S-EPMC6014638 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature