Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor.

ABSTRACT: The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires either the use of mediators or tedious biofunctionalization approaches. We report an all-polymer micrometer-scale transistor platform for the detection of lactate, a significant metabolite in cellular metabolic pathways associated with critical health care conditions. The device embodies a new concept in metabolite sensing where we take advantage of the ion-to-electron transducing qualities of an electron-transporting (n-type) organic semiconductor and the inherent amplificatio

SUBMITTER: Pappa AM 

PROVIDER: S-EPMC6014717 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature