INHBA upregulation correlates with poorer prognosis in patients with esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer. However, its clinical significance in esophageal squamous cell carcinoma (ESCC) has never been reported.

Patients and methods

In this study, we collected 239 ESCC paraffin-embedded specimens and measured the expression of INHBA with immunohistochemistry (IHC). The clinical and prognostic significance of INHBA expression was statistically analyzed. What is more, we conducted a meta-analysis to study the prognostic value of INHBA expression in multiple types of solid tumors.

Results

The results showed that INHBA expression was observed predominantly in the cytoplasm of cells in the ESCC specimens. INHBA expression was c

SUBMITTER: Lyu S 

PROVIDER: S-EPMC6014728 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature